tussis / cough reflex : the sequence of events
initiated by the sensitivity of the lining of the airways and mediated
by the medulla as a consequence of impulses transmitted by the vagus nerve,
resulting in coughing, i.e., the clearing of the passageways of foreign
matter, a sudden noisy expulsion of air from the lungs
dry or non-productive cough
: one not accompanied by expectoration
Manson's Oriental, endemic or parasitic
hemoptysis : a type of infestation with Paragonimus
westermani;
symptoms include coughing, spitting of blood, and gradual deterioration
of health
habit or psychogenic cough : coughing, usually in children, that
lacks a physical basis; it is a dry cough unaccompanied by other symptoms,
seen only during waking hours, often lasting for weeks, and refractory
to medication
reflex cough : a cough due to the irritation of some remote organ.
laryngeal reflex : a type of cough reflex in which irritation of
the fauces and larynx causes cough.
Arnold's nerve reflex cough syndrome / ear cough : a reflex cough
due to irritation of the area supplied by Arnold's nerve (the auricular
branch of the vagus nerve); this area is the posterior and inferior portion
of the external auditory canal and the posterior half of the tympanic membrane.
trigeminal cough : a cough due to irritation of the fibers of the
trigeminal nerve distributed to the throat, nose, and external meatus of
the ear.
dyspnea : breathlessness
or shortness of breath (SOB); difficult or labored breathing.
Laboratory examinations
: grading :
standard
Medical Research Council (MRC)
grade 1 : breathlessness with stenuous exercise
grade 2 : shortness of breath (SOB) when hurrying
on the level or walking up a slight hill (while going slowly upstairs the
upper floor or a mild slope, or fast walking in plain)
grade 3 : walks slower than people of the same age on the level OR stops
for breath when walking at own pace on the level (while walking normally
in plain with a healthy person with similar age)
grade 4 : stops for breath after walking 100 yards (forced to stop to recover
breathing while walking alone, slowly in plain)
grade 5 : too breathless to leave the house when dressing (forced to stop
to recover breathing while caring personal hygiene)
oxygen cost diagram (OCD)
baseline dyspnea index (BDI)
shortness of breath questionnaire (SOBQ)
exertional / exercise-induced dyspnea (EID)
Borg scale : a numerical scale for assessing dyspnea, from 0 representing
no dyspnea to 10 as maximal dyspnea
visual analog scale (VAS)
broad
chronic respiratory questionnaire (CRQ)
pulmonary functional status scale (PFSS)
pulmonary functional status and dyspnea questionnaire
(PFSDQ)
PFSDQ- modified version (PFSDQ-M)
Saint George respiratory questionnaire (SGRQ)
fatigue measures :
profile of moods state (POMS)
multidimensional assessment of fatigue (MAF)
multidimensional fatigue inventory (MFI)
exertional dyspnea : dyspnea
provoked by physical effort or exertion. NYHA subjective grading
:
cardiac dyspnea : distressful breathing caused by heart disease
I : no limitation of physical activity, symptoms with more than ordinary
activity (VO2, max > 20 ml/min/kg)
II : slight limitation of physical activity, symptoms with ordinary activity
(VO2, max = 16-20 ml/min/kg)
III : marked limitation of physical activity, symptoms with less than ordinary
activity (VO2, max = 10-15 ml/min/kg)
IIIa : no dyspnea at rest
IIIb : recent dyspnea at rest
IV : inhability to carry out any physical activity without discomfort;
symptoms at rest (VO2, max < 10 ml/min/kg)
Leredde's syndrome : severe dyspnea
on exertion, combined with advanced emphysema and recurrent attacks of
acute febrile bronchitis; seen in children with congenital syphilis (Treponema
pallidum subsp. pallidum)
while resting
platypnea / orthostatic dyspnea : difficulty
in breathing experienced when in the erect position.
pimelorthopnea / piorthopnea : dyspnea while lying down, due to
obesity
orthopnea : only when lying in the bed on
the back (increase of blood return to right atrium and increase of hydrostatic
pressure in lung interstitium allow acute
pulmonary edema)
orthopnea position : the patient assumes an upright or a semivertical
position by using two or more pillows to support his head and chest from
the recumbent position, or he sits upright in a chair. Used when the patient
has difficulty in breathing except in the upright position (orthopnea).
paroxysmal nocturnal dyspnea
: episodes of respiratory distress that awaken patients from sleep and
are related to posture (especially reclining at night), usually attributed
to cardiogenic
acute pulmonary oedema
(cardiac asthma) but sometimes occurring
in patients with chronic pulmonary diseases. During sleeping blood volume
increases due to hydroelectrolyte retention, reabsorption of oedema and
decrease in oncotic pressure in lung interstitium; it lasts for 10'-30'.
trepopnea : only when lying in the bed on
a flank
(bronchial, spasmodic or tracheobronchial) asthma
: recurrent attacks of paroxysmal dyspnea, with airway inflammation and
wheezing due to spasmodic contraction of the bronchi
Aetiology : bronchial airway
hyperresponsiveness (AHR) (an abnormality of the airways in which there
is an exaggerated bronchoconstrictor response to any of various physical
or chemical stimuli; seen in conditions such as asthma and sometimes COPD)
to ...
cardiac asthma : paroxysmal
nocturnal dyspnea that occurs in association with heart disease, such
as left ventricular failure
Anamnesis is important for diagnosis of occupational asthma (arrest/restart
test, attacks more severe on monday morning, stable or reducing during
week)
Laboratory examinations :
bronchial provocation, challenge
or provocative test / bronchoprovocation : a challenge test in which
a nonspecific agent is applied to the bronchi and they are assessed for
a bronchoconstriction reaction. A nebulizer is linked to a compressed-air-powered
dosimeter. Basal spirometry => spirometry 2' after 5 inhalations of the
buffering solution alone (positive control) => inhalation of nonspecific
agent and spirometry 2' after each dose :
methacholine chloride challenge
(a M3
agonist which acts as bronchoconstrictor : Lofarma liophilized metacholine
required dilution in 3 mL water) : a type of bronchial challenge or inhalational
challenge used as a test for airway reactivity or atopic asthma; aerosolized
methacholine 0.2% (2 mg/mL for 0.8"; each puff erogates 20 mg
metacholine; first puff => second puff after 0.55" => 2 puffs after 0.55"
(total = 80 mg)) => 1% (10 mg/mL for 1"; each
puff erogates 100 mg metacholine; first puff
=> 2 puffs after 0.55" => 4 puffs after 0.55" => 8 puffs after 0.55" =>
8 puffs after 0.55" (total = 2380 mg)) is applied
to the airways and the patient is assessed for responsiveness or hyperresponsiveness.
In babies methacholine has to be replaced with 6' of outdoor running. Test
is positive when provocative dose that causes a 20% decrease in FEV1
(PD20) < 1.2 mg
histamine
phosphate challenge : a type of bronchial challenge done to assess
responsiveness of the mucosa: histamine is applied to the nose or mucous
membrane and mucosal swelling is monitored; allergic or otherwise susceptible
subjects have lowered thresholds of reactivity
Contraindications : previously known hypersensitivity
to metacholine, acetylcholine or related compounds, previous anaphylactic
reactions, clinically manifest asthma, dyspnea or FEV1 <
70%, pregnancy or lactation
inhalational challenge / inhalational
provocation / inhalational challenge test : a type of challenge test
done to determine reactivity to drugs or causative allergens in atopic
or extrinsic asthma; a dilute concentrate of the suspected substance is
inhaled and the patient is assessed for bronchial reactivity, which may
be either early or late. It is often the only method for a legal aetiological
diagnosis of occupation asthma, as both in vivo tests and in
vitro serology are not available for many chemicals.
workplace PEF monitoring is still quite aspecific and workplace
also contains ubiquitary allergens
controlled occupational exposure : reproduction of the suspected
working activity in laboratory (poor reproducibility and difficult establishment
of threshold dose)
properly said specific bronchial provocation test : inhalation devices
for hydrophilic compounds and masks or exposure cabinets for unsoluble
compounds, gases or vapors allows to establish the inspirated dose
isocyanates (TDI, HDI, or MDI) vaporized at 100°C for 15' (20% of TLV)
dusts (wood, flour ammonium persulfate, dextrose, etc...) dried for 1 hr
at 50°C to reduce humidity => micronization according to granulometric
curve to produce PM10.
FEV1 and PEF are monitored for 24 hrs following exposure. Immediate
(within 1 hr), delayed (within 4-8 hours; 12-24 hours for TDI) or
dual
(both within 1hours and after 4-8 hours) responses correlate with follow-up
of the diseases after cessation of exposure.
specific nasal provocation test is no longer used
alveolar CO diffusion test (single-breath (0.3% CO) method for patients
with vital capacity > 1.7 L or averaged (0.1-0.2%))
residual volume test with He with average within 7' in normal patients
[eosinophils]plasma
[total IgE]plasma
< -1.5 folds normal value => P(asthma) = 0%
- 1.5 < x < 0.5 folds normal value => P(asthma) = 3%
-0.5 < x < 0.5 folds normal value => P(asthma) = 5%
0.5 < x 1.5 folds normal value => P(asthma) = 15%
> 1.5 normal value => P(asthma) = 30%
bronchodilatation or bronchodynamic test for patients with basal
FEV1 < 70% which can't undergo bronchial provocation test.
Test is positive when FEV1, 15' after administration of a b2-AR
agonists (2 puffs of salbutamol) / FEV1, before treatment
> 115%.
inspiratory dyspnea : difficulty in breathing caused by hindrance
to the free inspiration of air into the lungs.
nocturnal dyspnea : respiratory distress that is minimal in the
morning, and may gradually progress until it becomes quite disturbing at
night
nonexpansional dyspnea : difficulty in breathing caused by inadequate
expansion of the chest
apnea : the cessation of airflow at the nostrils
and mouth for > 10"
depression of respiratory centre (primary alveolar hypoventilation /
Ondine's curse : impairment of automatic control of respiration, usually
due to a spinal cord
injury
or brain stem lesion; voluntary control remains intact but central
sleep apnea
occurs)
deglutition apnea : a temporary
arrest of the activity of the respiratory nerve center during an act of
swallowing.
apnea neonatorum : failure of the
newborn infant to initiate pulmonary ventilation, leading to perinatal
asphyxia
initial or primary apnea : a condition
in which an infant fails to establish sustained respiration within 2' of
delivery. It is marked by initial tachypnea => respiratory arrest and severe
bradycardia, normotension of hypertension due to vasoconstriction of nonvital
organs; pale, responsive to physical stimuli and O2
late, secondary or terminal apnea : cessation
of respiration in an infant for > 45" after spontaneous breathing (irregular
gasping) has been established and sustained, marked by bradycardia, hypotension,
cyanotic skin, unresponsive to stimuli
apnea of prematurity : cessation
of breathing that lasts > 15 seconds and is accompanied by hypoxia or bradycardia
— occurs in at least 85% of infants who are born at < 34 weeks of gestationref.
Therapy : widely used treatments include
the application of continuous positive airway pressure and the prescription
of a methylxanthineref.
The methylxanthines — aminophylline, theophylline, and caffeine — reduce
the frequency of apnea and the need for mechanical ventilation during the
first seven days of therapyref.
However, it has remained uncertain whether methylxanthines have any additional
short- and long-term benefits or risks in preterm infantsref1,
ref2,
ref3.
Despite this uncertainty, methylxanthines have been the mainstay of the
pharmacologic treatment of apnea for the past 25 yearsref.
Methylxanthines are typically prescribed in very preterm infants until
they reach a postmenstrual age of 34 to 35 weeksref.
Drug exposure may last even longer. A recent study from the Neonatal Research
Network of the National Institute of Child Health and Human Development
showed that among infants with very low birth weight, 44% of those with
bronchopulmonary dysplasia and 21% of those without such disease were still
receiving methylxanthines at a postmenstrual age of 36 weeksref.
Caffeine
therapy for reduces the rate of bronchopulmonary
dysplasia in infants with very low birth weightref
sleep apnea / sleep-disordered breathing (SDB)
:
transient periods of cessation of breathing during sleep. It may result
in hypoxemia and vasoconstriction of pulmonary arterioles, producing
pulmonary
arterial hypertension (PAH).
The 2 primary types are :
central sleep apnea
/ central apnea
(no chest movement; please consider newborn are obliged nasal breathers
(e.g. in choanal atresia a permanent oral cannula is required) and chest
movements are usually minimal)
Moderate to severe SDB precedes stroke and may contribute to the development
of strokeref
hypopneas : a decrease in breathing in which
the airflow in and out of the airway is less than half of normal--usually
associated with oxygen desaturation. The presence of some airflow distinguishes
this event from apneic episodes.
bradypnea : < 10 breaths per minute
Aetiology : partial airway obstruction
Kussmaul-Kien
respiration / air hunger : a pattern of deep and rapid forced
inspirations and expirations to increase TV.
cogwheel, jerky or interrupted respiration : a form with a peculiar
jerky inspiration; the expiratory and inspiratory sounds are not continuous
but are split into two or more separate sounds
paradoxical respiration : respiration in which all or part of a
lung is deflated during inspiration and inflated during expiration, as
with flail chest or paralysis of the diaphragm.
puerile respiration : that in which the breathing sounds are more
intense than those of normal adult respiration and resemble those of childhood
divided respiration : respiration marked by a pause between the
inspiratory and expiratory sounds.
suppressed respiration : respiration without any appreciable sound,
as may occur in extensive consolidation of the lung, or pleuritic effusion
controlled diaphragmatic respiration : the intentional use of abdominal
respiration
for the purpose of limiting the motion of the apices of the lung
Biot's breathing, respiration or sign
: breathing characterized by irregular periods of apnea
lasting 20-30" alternating with periods in which 4-5 breaths of identical
depth are taken
Cheyne-Stokes'
breathing : breathing characterized by rhythmic waxing and waning of
the rate and depth of respiration, with regularly recurring periods of
apnea
lasting 40-50"; seen especially in coma resulting from affection of the
nervous centers.
Aetiology : lesions
of respiratory centre in the bulb, caused by ..
uncoordination of the 3 respiratory centres in newborns delivered before
pregnancy week 31 (apneas lasting < 10")
hyperventilation / overventilation
: a state in which there is an increased amount of air entering the pulmonary
alveoli in a given time. This results in reduction of PCO2,
alveoli
type II / global or ventilatory
respiratory failure : with respiratory
alkalosis.
In chronic failures the respiratory centre becomes tolerant to hypercapnia.
It is usually reversed by 7-8 days of resting of respiratory muscles, but
up to 10% cannot be weaned (in a 2-3 days time). Treatment : O2-therapy
=> inhibition of respiratory centre => increased hypercapnia,
noninvasive
mechanical ventilation (NIMV) if pH < 7.35 and O2 saturation
< 88%.
upper respiratory tract
(URT) is investigated by ears, nose and throat (ENT) / otorhinolaryngology
(ORL)
diseases of the nose / rhinopathy
/ rhinopathia (see also nose physiology)
congenital malformations
of the nose :
arhinia / arrhinia : congenital absence of
the nose.
hyporhinia : defective development of half
or the whole nose
macrorhinia : excessive size of the nose.
microrhinia : abnormal smallness of the
nose.
polyrhinia : overposition doubling of the
nose
congenital cysts
Therapy : surgical ablation at month 4-5
congenital fistulae
rhinocephaly : a developmental anomaly
characterized by the presence of a proboscis-like nose superior to eyes
that are partially or completely fused into one.
proboscis lateralis : a rare congenital
deformity marked by absence of the medial and lateral nasal processes and
the globular processes; on the affected side, the nasal cavity, choana,
and nasal bones are absent and there is a tubular appendage (proboscis)
above the medial canthus.
cleft nose : a developmental anomaly resulting
from incomplete union of the paired nasal primordia.
saddle, saddle-back
or swayback nose : concavity of the contour of the bridge of the nose
due to collapse of cartilaginous or bony support, or both
rhinolalia / rhinism / rhinophonia : altered
speech due to some abnormality of nasal structures
rhinolalia aperta
/ open rhinolalia / hypernasality : an excessively nasal quality of
voice, which may result in unintelligible speech; the cause is velopharyngeal
incompetence with emission of too much air through the nose
rhinolalia clausa / hyponasality
/ denasality : a quality of voice in which there is a complete lack
of nasal emission of air and nasal resonance, so that speakers sound as
if they have a cold
rhinolithiasis : the presence of rhinoliths / nasal calculi
(a nasal stone or concretion) in the nose.
rhinophyme
: a manifestation of severe rosacea involving the lower half of the nose
and sometimes spreading to adjacent cheek areas, usually seen in men, and
characterized by thickened, lobulated overgrowth of the sebaceous glands
and epithelial connective tissue.
Treatment : "hands off" policy, adequate doses
of appropriate antibiotics, hot, moist packs, and good analgesics; squeezing
or incising the area is dangerous, as it may cause septic of the facial
vein => angular vein => infectious
thrombophlebitis of cavernous sinus.
rhinokyphosis : the presence of an abnormal hump in the ridge of
the nose.
nasal septal deviation
Therapy : surgical correction
nasal septal perforation
Aetiology : Hajek trophic nasal septal
ulcer
idiopathic (associated with simple atrophic rhinopathy)
granuloma gangraenescens
: a condition beginning with the formation of proliferating granulations
in the nasal mucous membrane which invade the adjacent tissues and soon
become gangrenous
Epidemiology : Egypt, Eastern Europe,
and Central and South America.
Aetiology : Klebsiella
pneumoniae subsp. rhinoscleromatis Symptoms & signs : hard patches or
nodules (scleroma) form on the nose and nasopharynx
rhinitis : inflammation
of the mucous membrane of the nose.
rhinolaryngitis : inflammation of the mucous membrane of the nose
and larynx
rhinosalpingitis : inflammation of the nasal mucosa and the eustachian
tube.
rhinoantritis / nasoantritis : inflammation of the nasal cavity
and the antrum of Highmore
rhinotracheitis : inflammation of the nasal mucous membranes and
trachea.
acute catarrhal rhinitis / coryza :
an acute congestion of the mucous membrane of the nose, marked by dryness,
followed by increased mucous secretion from the membrane, impeded respiration
through the nose, and pain
rhinitis caseosa : rhinitis with a caseous, gelatinous, fetid discharge
Aetiology :
infectious rhinitis
acute viral rhinitis / common cold
respiratory viruses : an epidemiologic class of viruses that are
acquired by inhalation of fomites and replicate in the respiratory tract,
causing local rather than generalized infection. Respiratory viruses are
included in the families
acute bacterial rhinitis can develop as a
complication of an URT infection (URI) if symptoms last longer than 7-10
days. Thick yellow or greenish nasal drainage, fever,
throat and ear pain, and productive cough suggest complications. Excessive
blowing of the nose, which forces bacteria into the sinuses and Eustachian
tube and traumatizes the sinus orifices, and severe coughing, which strips
the cilia from the bronchial lining, are the most common causes.
Treatment : maintaining good nasal and sinus
drainage, good tissue hydration, and rest; antibiotics are used for bacterial
infections or complications. The penicillins, erythromycin, or the tetracyclines,
in order of preference, handle most complications, but cultures should
be taken to provide help in resistant cases.Even a slight amount of nasal
congestion and tissue edema may be enough to interfere with pressure equalization
of the sinuses and ears, leading to aerotitis
media,
aerosinusitis,
or barometric vertigo.
Symptoms & signs : acute congestion of
the mucous membrane of the nose, marked by dryness, followed by increased
mucous secretion from the membrane, impeded respiration through the nose,
and pain
chronic rhinitis : long-term inflammation
of nasal mucous membranes
hypertrophic rhinitis : a form
of rhinitis that is nonallergic and noninfectious, and in which the mucous
membrane thickens and swells
vasomotor rhinitis / rhinopathia vasomotoria
:
a form of hypertrophic rhinitis with symptoms similar to those of allergic
rhinitis; transient changes in vascular tone and permeability are brought
on by such stimuli as chilling, fatigue, anger, and anxiety
Aetiology :
intrinsic : neurovegetative dystonia with parasympathic prevalence
extrinsic : changes in temperature, humidity, emotional states, ....
Epidemiology : females with age 40-60
Symptoms & signs : no sneezing, no
narix alternation
atrophic rhinitis : a chronic form
of rhinitis that is nonallergic and noninfectious, marked by wasting of
the mucous membrane and the glands
syphilitic rhinitis : a variety
caused by Treponema
pallidum subsp. pallidum,
and marked by ulceration, caries of the nasal bone, and a fetid discharge.
tuberculous rhinitis : a variety
due to Mycobacterium
tuberculosis,
and attended with ulceration, caries of the nasal bone, and ozena
gangrenous rhinitis : a gangrenelike
inflammation of the nasal mucosa
cancrum nasi : gangrenous rhinitis of
children
fibrinous, membranous or pseudomembranous rhinitis : chronic rhinitis
with the formation of a false membrane, as in nasal Corynebacterium
diphtheriae
rhinomycosis : fungal infection of the
nasal mucosa
rhinoentomophthoromycosis /
rhinofacial zygomycosis : the usual form of entomophthoromycosis conidiobolae,
marked by development of large polyps in the subcutaneous tissues of the
inferior turbinates of the nose and paranasal sinuses; orbital involvement
with unilateral blindness may follow. Sometimes, especially in weak or
immunocompromised patients, it can spread to the central nervous system
and cause fatal rhinocerebral zygomycosis.
Aetiology : a microscopic round body in
polypoidal masses
the sporangium of Rhinosporidium
seeberi
: fungal aetiology can not be proved with certainty. Attempts to culture
the fungus on various media have also been unsuccessful
Microcystis aeruginosa.
The new findings justify a change in the name "rhinosporidiosis" that had
been associated with the fungus Rhinosporidium seeberi
Symptoms & signs : a chronic, localized
granulomatous infection affecting mucocutaneous tissues, usually of the
nose but sometimes elsewhere in the body; characterized by polyps, papillomas,
and other wartlike lesions.
Therapy : complete abstinence from nose drops.
In about three weeks, the normal reflex activity should return
Lasting :
intermittent : < 4 days per week, or < 4 consecutive weeks
persistent : > 4 days per week, or > 4 consecutive weeks
Grading :
mild
moderate / severe : sleeping alterations, limitation of daily activities,
reduction of workplace performances, severe symptoms
Symptoms : chronic, intermittent, often alternating
nasal stuffiness or obstruction, and postnasal dried if they are a factor
in obstructions
Therapy :
antibacterials
: amoxicillin + clavulanic acid + cefpodoxime or cefurioxime for 8-10 days
analgesics
antipyretics
decongestant drops (phenylephrine 0.25-0.50% p.o. in adults)
prevent drying of the mucosa
Proetz solution or ointments
humidification of the house or bedroom. Air conditioners may contain much
dust and mold, causing more trouble for a person with allergies to these
substances. Electrostatic filters may do a better job, but may produce
ozone which is toxic. If the first outlet is 8-10 feet from the unit, it
is usually safe. Humidification is good for the dry nasal mucosa, but it
also increases the growth of molds in the house.
‡
polypoid degeneration : the
anterior tip of the middle turbinate remains edematous
‡
polyps : with the help of gravity, the paranasal
mucosa elongates, especially in the region of the middle meatus and maxillary
sinus ostia. The tissue may lose some of its cilia and is replaced with
goblet cells.
nasal polyp / rhinopolypus may obstruct
the sinus ostia leading to acute and chronic sinus disease or sinus
blocks and, therefore, should be removed when obstructive. Small, or
single, nonobstructive polyps need not be removed unless they enlarge.
adenofibroma edematodes : a tumor composed of glandular and connective
tissue elements in which there is marked edema of the stroma, as in nasal
polyp.
short courses (2 sprays in each nostril, twice daily for 1 week, then 1
spray in each nostril twice daily for 4 days, finishing with 1 spray daily
in each nostril for the remainder of the week or longer, if desired) of
broad spectrum and topical steroids, such as aerosol Decadron or
Beclamethazone, may reduce the size of the polyps. The use of topical steroids
may be irritating to the mucosa, and use beyond 1 month is not recommended
antibiotics
surgical removal : recurrence is common; this is especially true
when the disease remains in the ethmoid sinuses
rhinonecrosis : necrosis of the nasal bones.
inverted schneiderian papilloma : a neoplasm of the nasal wall,
having destructive capacity, a tendency to recur, and a potential for malignancy
rhinorrhea : the free discharge of a thin
nasal mucus.
passive nasal congestion due to compression of superior vena cava, anonymous
veins, or jugular veins (mediastine neoplasms, thymus
neoplasms, thyroid
cancers)
ethmoid artery, a branch of the internal carotid artery (high
anterior epistaxis)
Kisselbach's plexus (intracapillary vessels are named Kubo capillaries)
in locus Valsalvae / Little's area (low anterior epistaxis)
Therapy :
control
direct pressure, for at least 5-10', against the anterior septum
pledgets of cotton moistened in a vasoconstrictor, such as 1% Neo-Synephrine,
1% epinephrine, or 1-4% cocaine, along with pressure, are even more effective
cauterization
chemical cauterization with 25-50% trichloroacetic acid, 5% chromic
acid, or silver nitrate in a 50% solution or on a stick applicator. These
solutions should be applied with a small, moist applicator under direct
vision.
electrocauterization : deep burns or cauterization of adjacent structures,
such as the ala or vestibule, must be avoided. If the coagulated fluid
and blood stick to the tip of the cautery and are pulled off with the coagulum,
the bleeding may restart. In those cases where bleeding cannot be controlled,
one might attempt cautery with a suction tip electrode; if this fails,
the nose can be packed with Vaseline and antibiotic ointment impregnated
in half-inch selvage gauze. It is best to pack both sides to prevent loss
of the pack by shifting of the septal cartilage from a one-sided pressure.
The pack should be left in place for 24-72 hours. All raw or cauterized
surfaces should be lightly covered with an antibiotic ointment, and a small
piece of compressed Gelfoam over the anterior septum further protects against
air trauma. The ointment application should be repeated 3-4 times a day.
posterior epistaxis (from the
sphenopalatine
artery, a branch of the external carotid artery, in posterior part
of vomer and Woodruff zone (posterior third of meatus inferius
on lateral wall)), usually in the older age group, is a serious condition
when coupled with systemic
arterial hypertension
Therapy :
the patient should be admitted to sickbay, sedated, and kept in a head-elevated
position. After vasoconstrictor and topical anesthestic application to
both nasal passages, a specifically designed postnasal balloon,
or a common, 15 cc-size Foley catheter is passed along the floor
of the nose, and when it is in the lower nasopharynx, it is filled with
about 5 cc of water. It is then drawn back up against the posterior choana
and further filled to the point of tolerable discomfort to the patient.
Anterior packing is inserted bilaterally with fixation of the catheter
to the lip or against the packing, but never against the ala or septum
to prevent pressure necrosis. The posterior pharynx is checked hourly for
bleeding, and the hemoglobin and hematocrit are monitored according to
the amount of oozing or bleeding; blood typing and cross matching are advisable.
Blood coagulation studies are usually done, but it is unusual to see only
nasal bleeding with abnormality of the clotting mechanism. A patient with
a posterior nasal pack or balloon should be closely monitored because of
the possibility of a nasovagal reflex action when the nasopharynx
is packed, that might lead to apnea or hypoxia.
sinonasal
undifferentiated carcinoma (SNUC) is a rare aggressive neoplasm arising
in the nasal cavity and paranasal sinuses (expecially ethmoid sinus); first
described in 1986
Epidemiology : median age = 53 years (range
20-76 years); male/female ratio of approximately 2:1
Aetiology : previous nasopharyngeal carcinoma
treated with irradiation 6-26 years earlier; no relation with HHV-4
/ EBV Microscopic anatomy : cohesive cells arranged
in nests, ribbons, and trabeculae. The cells exhibit hyperchromatic nuclei
and a high nuclear to cytoplasmic ratio. A brisk mitotic rate, tumor necrosis,
and vascular invasion are prominent features
Symptoms & signs : facial pain, nasal
obstruction, diplopia, epistaxis, proptosis, and periorbital swelling;
orbital and intracranial invasion and distant metastasis are frequent findings
Prognosis : median survival is 10 months
mucocele : dilatation of a paranasal sinus(es)
with accumulated mucous secretion => pyocele
Therapy : major surgical procedure
solitary Killian antrochoanal
polyp : polyps within the maxillary sinus that eventually move out
of the sinus ostium and into the nasopharynx, where they expand in size.
Therapy : surgical removal requires a
Caldwell-Luc
antrostomy to remove the base
As an aviator goes to altitude, the outside pressure decreases, and discomfort
may be felt in the obstructed sinus. It is usually not severe, however,
and most often air forces its way out past the obstruction. When the aviator
descends, the pressure in the obstructed sinus remains less than the surrounding
pressure, creating a vacuum effect on the delicate, thin, mucosal lining
and resulting in pain that is often severe. Some fluid may be drawn into
the cavity, but the more serious complication is pulling away of the mucoperiosteum,
with formation of a hematoma. Sinus blocks occur most often in the frontal
sinus (70%).
Symptoms & signs : Ewing sign
: tenderness at the upper inner angle of the orbit: a sign of obstruction
of the outlet of the frontal sinus.
Laboratory examinations : sinus X-ray
Waters' position : the position of the head in Waters' projection
(a radiographic projection of the anterior head, used for viewing the maxillary
sinuses and sphenoid bone; the central ray enters at an angle through the
chin)
reverse Waters' position : a mento-occipital radiographic position
used to demonstrate the facial bones when the patient cannot be placed
in a prone position; helpful in demonstrating fractures of the orbits,
maxillary sinuses, zygomatic bones, and zygomatic arches
Caldwell's position : a radiographic position with the forehead
and nose against the x-ray plate, used with Caldwell's projection
(a posteroanterior projection of the head, used for viewing the frontal
and anterior ethmoidal sinuses; the central ray enters the back of the
head from a slightly superior angle)
Toynbee experiment or maneuver : pinching the nostrils and swallowing;
if the auditory tube is patent, the tympanic membrane will retract medially
Treatment of the acute block :
stop descent in aircraft or low-pressure chamber, if possible, and return
to altitude for pain relief
if available, spray the nasal passage with a vasoconstrictor nasal spray
(nose drops).
do the Valsalva's maneuver, method or test (forcible exhalation
effort against occluded nostrils and a closed mouth causes increased pressure
in the eustachian tube and middle ear, so that the tympanic membrane moves
outward. Formerly used as a test of patency of the auditory tube) or use
the Politzer method
make a slow descent equalizing pressure with the above maneuvers
place patient on antihistamine-decongestant or decongestant therapy.
if an upper respiratory infection is present, treat with antibiotics.
Therapy : since recent use of antibiotics
increases the risk of infection due to resistant organisms, the guidelines
also divide patients according to antibiotic exposure in the previous 4-6
weeks.
mild disease with no recent antibiotic use (past 4-6 Weeks)
mild disease with previous antibiotic use or moderate disease
ethmoid sinusitis / ethmoiditis
(the most common) : inflammation of an ethmoidal sinus, often associated
to frontal and maxillary sinusitis due to proximity. Pain may be near the
root of the nose or frontal region. Edema of the lower lid is often present
in children. Orbit involvement may result in painful eye movement due to
a periostitis about the pulley of the superior oblique muscle or, in the
case of rupture into the orbit, proptosis.
ethmoidomaxillary sinusitis usually has the least toxicity and the
maxillary sinus mucosa has great reparative power. Antral cysts,
which are frequently seen on the Waters X-ray as a smooth, rounded density
in the lower aspect of the maxillary sinus, are benign, filled only with
clear or xanthochromic fluid. They usually require no treatment, unless
they fill the sinus, obstruct drainage, and lead to symptoms.
ethmoidofrontal sinusitis usually : toxicity, frontal headache,
often in mid-morning to late afternoon, tenderness to percussion over the
sinus, or pressure on the floor in the supraorbital region, swelling of
the upper eyelid
ethmoidosphenoid sinusitis (uncommon) : deep, boring, occipital
or parietal headache
with inability to concentrate, fever,
malaise, and anorexia
frontal sinusitis : inflammation of a frontal sinus.
maxillary sinusitis / antritis : inflammation of a maxillary sinus
sphenoid sinusitis / sphenoiditis : inflammation of a sphenoidal
sinus
Complications :
bony complications : osteomyelitis of anterior wall of frontal bone
postnasal drip : the dripping of discharges from the postnasal region
into the pharynx due to hypersecretion of mucus in the nasal or nasopharyngeal
mucosa or to chronic sinusitis.
pressure or pain over the involved sinus
pus draining from the middle meatus or above the middle turbinate
toxicity is usually mild, except in cases of pansinusitis when the
frontals or sphenoids are involved
Citelli's syndrome : mental dullness, loss of power of concentration,
and drowsiness or insomnia, seen in persons with adenoids or sinus infection.
submental vertex positions to detect sphenoid sinusitis
Treatment :
protect the nasal mucosa from drying (hydratation, humidification,
vaporization)
oral decongestant alone or with a mucous-thinning medication (glycerial-guiacolate)
antibiotics for at least 7 days
p.o. in most uncomplicated cases
i.v. in pansinusitis or cases of moderate to severe toxicity, and especially
in frontal or sphenoid involvement
While taking sample to culture for antibiogram, be sure not to touch the
nasal vestibule and hairs, as these areas may have different predominant
organisms. The nasopharynx is another area from which to obtain a culture
of prevalent sinus drainage.
removal of the pus by antral irrigation is indicated for persistent
pain or fluid levels after 48 hr of antibiotic therapy. Nasal irrigations
may enhance the movement of mucus toward the nasopharynx, or may function
to remove inflammatory mediators, such as histamine, prostaglandins, and
leukotrienes, contained in nasal mucous. While a number of studies have
found hypertonic and isotonic solutions comparable, one study showed that
hypertonic solutions were significantly more effective in improving mucociliary
clearance in volunteers without significant sinonasal disease. Additionally,
it is unclear how important use of a sterile or buffered solution may be.
Antibacterials
and antifungal agents are the most common additives : an additive of interest
is xylitol, a naturally occurring sugar that lowers the salt concentration
of airway surface liquid and appears to upregulate antimicrobial factors.
Delivery of the nasal solution can be by positive-pressure squeeze, negative
pressure, or nebulizers. Of these, the nebulizer may be least effective,
as evidence suggests that this method does not deliver solution to the
sphenoidal or frontal sinuses.
maxillary sinus irrigation
inferior meatus puncture
anesthesia
spray mucosa initially with a vasoconstrictor.
for local anesthesia use 4-5% topical cocaine and 2% Xylocaine with Epinephrine
1:1000 (dental carpule or equivalent).
apply pledgets of cotton moistened with cocaine (never sloppy wet) in the
inferior meatus and on the inferior turbinate. After initial application,
cocaine on a wire applicator is placed against the lateral wall of the
inferior meatus about one inch or 1.5 to 2.5 cm behind the anterior edge
of the meatus for 5'
insert a long (3 1/2 inch) needle into the inferior meatus until it strikes
bone in the area of the intended puncture and infiltrate with local anesthetic.
equipment
straight 3 1/2 inch, 18 gauge spinal needle or equivalent trocar with stylet.
sterile saline to which a small amount of Neo-Synephrine may be added.
1 30-50 cc syringe and one 5 cc syringe.
plastic or rubber extension tubing.
culture tube
technique
with the patient in an upright position and the head against a firm headrest,
the puncture needle or trocar is inserted into the inferior meatus about
2 cms posterior to the edge of the inferior meatus and engaged in the thin
bone of the lateral wall of this area.
the thumb is placed against the stylet and the needle is directed laterally
in line with the outer canthus of the eye, using the fingers of the opposite
hand to steady the needle. Pressure is slowly, but steadily, increased
until the needle is felt to penetrate into the sinus.
the needle is pushed into the sinus until it strikes the lateral sinus
wall and then withdrawn about one centimeter. If a low-lying cyst is present,
the needle is directed as far inferior as possible just after penetration
to puncture the cyst.
direct observation of the drainage or aspiration with a small syringe may
be diagnostic or produce a pure specimen for culture.
the large syringe and extension tubing filled with normal saline are inserted
into the needle and aspiration is attempted. Air bubble or exudate indicates
the needle is in the proper position. No aspiration may mean the needle
is in the mucosa, plugged, or not inn the sinus proper.
irrigation is carried out with the patient leaning forward over a large
basin with his mouth open, and gentle, but steady, pressure is applied
to the syringe.
instant, severe pain suggests the needle is in the mucosa; readjust the
needle's position and repeat. Intolerance to irrigation pressure dictates
termination of the procedure and possible attempt at natural ostia irrigation.
A slow buildup of pressure and occasionally pain is expected with an obstructed
ostia, but it is usually tolerable or relieved as the sinus is irrigated.
irrigation should be carried out until the washing is clear or, in the
case of a clear irrigation, until at least three full syringes have been
used.
the final irrigation should be made with the sinus ostia dependent. Insufflation
of air into the sinus has been associated with air isolation and should
not be performed.
the needle is withdrawn with a smooth rapid movement and the nasal passage
immediately inspected for retained pus or thick mucus. This material is
aspired, being sure to include aspiration of the posterior floor and middle
meatus.
natural sinus ostia (not recommended)
anesthesia
use 4-5% cocaine for local anesthesia.
vasoconstrict the mucosa.
apply cocaine-moistened pledgets in and around the middle meatus. A long
applicator containing cocaine may also be inserted posteriorly against
the area of the sphenopalatine nerve exit.
equipment : a maxillary sinus cannula plus the equipment used for the puncture
technique are required.
technique
a maxillary sinus cannula is inserted posteriorly into the middle meatus
and slowly brought forward with the tip probing for the ostia in the hiatus
semilunaris. When the cannula passes into the ostia, it should be anchored
with tape to the nose or held in place by the physician.
aspiration and irrigation are carried out in the same manner as for the
needle irrigation.
Proetz displacement technique can be used for irrigation of the
frontal, sphenoid, and maxillary sinus as well as for the ethmoid sinus
in nonacute (subacute or persistent) disease.
equipment
a controlled vacuum source.
sterile 100 cc solution container.
Proetz vacuum apparatus (curved olive tip glass collection bottle).
sterile bulb or other syringe, 20 cc or larger.
sterile normal saline into which may be added Neo-Synephrine, not to exceed
a total of 1/8%
technique
place the patient supine, with head lowered over the edge of the table.
instruct the patient to breathe only through the mouth and not to swallow
or talk until instructed.
fill the nose and nasopharynx with the solution through one nostril.
insert the soft rubber or steel olive tip of the vacuum apparatus into
one nostril, with no more than 180 mm Hg of vacuum.
close the opposite nostril and have the patient say K-K-K-K-K-K-K-K.
repeat the procedure several times in each side, or until purulent material
is no longer present.
stop immediately if the patient has severe pain, or if blood is noted in
the irrigation fluid.
give the patient a rest and allow him to sit up to drain out the nose several
times during the procedure.
daily mucosal shrinkage and gentle nasal suction cleaning may help promote
drainage.
local heat to increase the vitality of the mucosa.
... ethmoid sinus : removal is most difficult and is done with an intranasal
approach when polyps and persistent disease are present
... sphenoid sinus (rare, but most difficult to diagnose, because X-rays
may be inconclusive and symptoms extremely variable)
... frontal sinus : bicoronal incision flap approach or the osteoplastic
eyebrow incision approach, with complete removal of the sinus mucosa
and obliteration of the sinus, usually with fat. These surgical procedures
and treatment may not result in relief of nasal symptoms or remove the
tendency toward recurrent infection.
Web resources : Sinusitis
by Wellington S. Tichenor, M.D.
hemosinus / haemosinus : a collection of
blood within a paranasal sinus
pneumosinus dilatans : abnormal
dilatation of the sphenoidal sinuses with remodeling but without erosion
or thinning of the sinus bony walls. The sinuses are well aerated and the
mucosa is normal. Sometimes associated with pneumocephalus
diseases of the rhinopharynx
rhinopharyngocele : an aerocele of the nasopharynx.
rhinopharyngolith : calculus of the nasal pharynx.
rhinopharyngitis / nasopharyngitis /
epipharyngitis : inflammation of the rhinopharynx
Pathogenesis : exudate in upper reaches
of the nasopharynx
Symptoms & signs : toxic and febrile,
with pressure or pain in the ears, a severe headache,
or retrobulbar pain. Usually, the oropharynx is somewhat inflamed, and
there is occasionally neck stiffness or edema of the uvula
Therapy : I.M./I.V. antibiotics initially,
plus supportive
adenoiditis : inflammation of the adenoid
tissue of the nasopharynx.
juvenile nasopharyngeal
angiofibroma / nasopharyngeal angiofibroma or fibroangioma : a benign
tumor of the nasopharynx composed of fibrous connective tissue (hard
fibroma / fibroma durum) with abundant endothelium-lined vascular spaces,
usually occurring during puberty, most commonly in males
adenocarcinoma
lymphomas
nasopharyngeal carcinoma (NPC)
: a malignant tumor
type 1 : squamous cell carcinoma (SCC), typically found in the older
adult population
type 2 : non-keratinizing carcinoma
type 3 : anaplastic or undifferentiated
NPC / primary sinonasal nasopharyngeal-type undifferentiated carcinoma
(PSNPC) / undifferentiated squamous cell carcinoma carcinoma of the nasopharyngeal
type (UCNT) / lymphoepithelioma / lymphoepithelial carcinoma / Schmincke's
or Regaud's tumor (33%; 33% of all nasopharyngeal cancers of childhood)
: a pleomorphic, poorly differentiated (transitional cell) carcinoma arising
from modified epithelium overlying the lymphoid tissue of the nasopharynx;
first described as a separate entity by Regaud and Schmincke in 1921
(Regaud C & Reverchon L. Sur un cas d'épithélioma epidermoide
développé dans le massif maxilaire supérieur étendu
aux téguments de la face, aux cavités bucclaes, nasales et
orbitaires, ainsi qu'aux ganglions du cou, guéri par la curiethérapie.
Rev.Laryngol.otol.Rhinol. (Bordeaux) 42:369 (1921); Schminke A. Ueber lympho-epitheliale
Geschwulste. Beitr.Anat.Allg. Pathol. 68:161 (1921)). It is now considered
a WHO type 3 lesion
Epidemiology : incidence = 0.5 every 100,000
/ yr in Europe; 10-30 every 100,000/ yr in China, South-Eastern Asia, Alaska,
Greenland, Northern Africa and Mediterranean basin; male-to-female ratio
2-3:1; peak age of onset : 10-20 and 40-60 years (range 36-75 years)
Aetiology : HHV-4
/ EBV.
It is estimated that the risk of rhinopharyngeal cancer is 20% in Chinese
with high levels of anti-VCA IgA.
Microscopic anatomy : vesicular nuclei,
syncytial pattern, non-keratinizing spindle cells, and absence of necrosis.
Many of these tumors show a marked infiltration of lymphocytes justifying
the term "lymphoepithelioma" used to define these tumors in the past. This
recruitment from the underlying lymphatic tissue could be determined by
the expression, on the part of the basal cells of tonsillar crypts, of
ICAM-1 and VCAM-1ref.
Therapy : radiotherapy
Prognosis : OS= 65%
The Cologne modification of the WHO scheme by Krueger and Wirstow
includes the degree of lymphoid infiltration. Types 2 and 3 may be accompanied
by an inflammatory infiltrate of lymphocytes, plasma cells, and eosinophils,
which are abundant, giving rise to the term lymphoepithelioma. 2 histologic
patterns may occur:
Regaud type, with well-defined collection of epithelial cells