Scaffold mediated assembly of signaling pathways.
A; Jip1 acts as a scaffold for the mammalian Jnk MAPK cascade. Jip1 has separate binding sites for Jnk, and the upstream kinases MKK7 (MAPKK), MLK3 (MAPK), and HPK1. Jip1 also has SH3 and PTB domains that may tether the complex to additional proteins involved in upstream activation or localization.
B; The Erk MAPK docks to target proteins. Once tethered in this manner, Erk phosphorylates the substrate, Rsk1.
C; The regulatory cyclin A subunit of Cdk2 binds substrates with a conserved RXL motif, such as p107.
D; The AKAP protein Yotiao binds to the NMDA receptor, PKA in the inactive form, and PP1 in the active form. In doing so, Yotiao creates close physical association of the components that repress resting NMDA receptor and enhance channel activation.
Copyright © 2001-2005 Daniele Focosi.
All rights reserved
| Terms of use | Legal
notices
|
|
|
|
|
